Graffanino is primarily a contact hitter (just 481 strikeouts in 2787 big-league at-bats) who is able to get on base (career .336 OBP) – and his speed is above average, with 53 stolen bases in 78 attempts. He excels as a situational hitter, being capable of hitting behind the runner and dropping down a bunt. As a fielder, he has the ability to play every infield position and left field. He has an above-average arm, which helps him in the LF and on the left side of the infield.
During Graffanino's minor league career, he spent time with Pulaski in 1990, the Idaho Falls Braves of the Pioneer League in 1991, the Macon Braves of the South Atlantic League in 1992, the Durham Bulls in 1993 and the Greenville Braves of the Southern League in 1994.
After spending three years with the Atlanta Braves, 2 1⁄2 seasons with the Tampa Bay Devil Rays, and another 3 1⁄2 with the Chicago White Sox, Graffanino played only second base for the Kansas City Royals in 2004, but moved around more in 2005. Obtained by the Boston Red Sox after the All-Star Game, he started at second base following the cut of Mark Bellhorn.
In 2005, Graffanino hit .298 for the Royals and .319 with the Red Sox for a combined .309 (117-for-379), a career high. He also posted career numbers in RBI (38), runs (68), doubles (17), games (110), and hits. He received some notoriety, particularly in New England, for making an error in the fifth inning of Game Two of the 2005 American League Division Series which led to three unearned runs. The runs came on a two out, three run home run by White Sox 2B Tadahito Iguchi which proved to be the game winning hit. The Red Sox were swept in that series.
In 2007, Graffanino struggled to begin the year, but after the call up of talented prospect Ryan Braun, Graffanino seemed to be invigorated and raised his sub .200 batting average to over .240 over a month's time. He slugged nine home runs in only 231 at bats that season. But on August 8, Graffanino tore his ACL, ending his season with a .238 batting average. After the 2007 World Series, he officially became a free agent.
On June 24, 2008, he signed a minor league contract with the Cleveland Indians. He hit .315 in 25 games and became a free agent at the end of the season.
- Graffanino has been very active in the community during his career. in 2002, he coordinated and led baseball clinics for boys and girls from Mercy Home at U.S. Cellular Field and signed autographs at the James R. Thompson Center to promote the need for organ donors.
- Graffanino was born Anthony Graffagnino but dropped the "g" after numerous mispronunciations from minor league announcers.
- Grew up in East Islip, New York, also home town to football great Boomer Esiason.
- Graffanino lives with his wife, Nicole, and two sons, A.J. and Nicholas, in Hockessin, Delaware.
- Nickname is "Trout".