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Southeast Missouri League was an independent league, unknown if this league played from 1921 to 1923 or before 1919 and after 1927
1919 Cape Girardeau MO, Charleston MO, Illmo, MO, Sikeston MO
1920 Caruthersville MO entered the league; Illmo has left the league.
1924 Campbell MO, Cape Girardeau MO, Caruthersville MO, Dexter, MO, Kennett MO, Malden MO, Poplar Bluff Mo, Sikeston MO
1925 Charleston Mo, Cairo Il, and Doniphan Mo enter the league and Campbell, Caruthersville and Cape Girardeau has left the league
1926 Unknown if this league played
1927 Cairo IL, Cape Girardeau MO, Chaffee MO, Dexter MO, East Prairie MO, Popular Bluff MO and Sikeston MO