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Manuel was called up the majors in July 7, 2009. Manuel made his major league debut on July 9, 2009 against the Philadelphia Phillies, pitching 1 1/3 innings, striking out two, allowing two hits and walking two, the first player he faced was Pedro Feliz and the first player Manuel struck out was Paul Bako.
On November 20, 2009, Manuel was claimed off waivers by the Boston Red Sox. He was designated for assignment on February 10. Manuel was added to the 40-man roster in June.