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The Mississippi Valley League operated as a Class D organization from 1922 to 1932. It was upgraded to Class B for the 1933 season. It was independent in 1919.
- Burlington, IA: 1919, 1924-32
- Cedar Rapids, IA: 1919, 1922-32
- Davenport, IA: 1919, 1929-33
- Dubuque, IA: 1919, 1922-32
- Keokuk, IA: 1919, 1929-33
- Marshalltown, IA: 1922-28
- Moline, IL: 1919, 1924-32
- Ottumwa, IA: 1922-28
- Peoria, IL: 1933
- Quincy, IL: 1933
- Rock Island, IL: 1919, 1922-33
- Springfield, IL: 1933
- Waterloo, IA: 1922-32