Guthrie was born in Roseburg, Oregon and grew up in Ashland, Oregon, attending Ashland High School. Then he attended Brigham Young University before transferring to Stanford University, where he was a starting pitcher. Guthrie served a two-year mission for The Church of Jesus Christ of Latter-day Saints in Spain. He currently lives in Arizona with his wife Jenny and his daughter Avery. 
He was called up to the Major Leagues to work out of the bullpen on two different occasions. He has worn #57 for both the Indians and the Bisons.
During the 2007 season, he has become one of the best and most consistent pitchers in the American League, ranking 2nd in ERA and allowing more than 2 earned runs in just 1 out of 10 starts. He is also 1st in the AL in WHIP (Walks and Hits per Innings Pitched).
After being called up to fill a spot in the Baltimore Orioles' bullpen and then moving into the starting rotation, Guthrie has enjoyed a breakout year in 2007. Through the end of July 2007, Guthrie has a 7-3 record in 17 starts to go with a sparkling 2.89 ERA and a 1.027 WHIP (second only to 2-time Cy Young award winner Johan Santana), albeit in only 124.7 innings of work. Guthrie's rise to unexpected success in the first half of the season has led to consideration for the American League's Rookie of the Year Award.
- ↑ Phillips, Mike. "Orioles' Guthrie on the rise again", Miami Herald, January 24, 2008. Retrieved on 2008-02-28.
- ↑ The Official Site of The Baltimore Orioles: Team: Player Information
- ↑ The Official Site of Major League Baseball: News: Major League Baseball News