At the age of 10, Betances was a Yankee fan who sat with the Bleacher Creatures for the perfect game of former Yankees pitcher David Wells in 1998. He credits his family taking him to Yankee games with his choosing baseball over basketball.
He attended Grand Street Campus School in Brooklyn, New York. In 2005, Betances was an Aflac All-American and played for the Team USA Junior National Team. Betances played baseball in the summer in the Youth Service League.
Betances spent 2007 with the Class-A Short Season Staten Island Yankees and 2008 with the Class A Charleston RiverDogs. In 2009, he pitched for the Tampa Yankees, the Yankees Class A-Advanced affiliate. Betances had surgery late in the 2009 season, which was erroneously reported as Tommy John surgery, but was instead a ligament reinforcement procedure.
Following the 2010 season, Betances was added to the Yankees' 40 man roster. He began the 2011 season with the Double-A Trenton Thunder, and was promoted to the Triple-A Scranton/Wilkes-Barre Yankees on August 13.
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