The 2000 American League Division Series (ALDS), the opening round of the 2000 American League playoffs, began on Tuesday, October 3, and ended on Sunday, October 8, with the champions of the three AL divisions – along with a "wild card" team – participating in two best-of-five series. The teams were:
- (1) Chicago White Sox (Central Division champion, 95-67) vs. (4) Seattle Mariners (Wild Card, 91-71): Mariners win series, 3-0.
- (2) Oakland Athletics (Western Division champion, 91-70) vs. (3) New York Yankees (Eastern Division champion, 87-74): Yankees win series, 3-2.
The higher seed (in parentheses) had the home field advantage (Games 1, 2 and 5 at home), which was determined by playing record. The team with the best record was assigned to play the wild card team, unless they were in the same division. The Athletics were not required to make up their one remaining game against the Tampa Bay Devil Rays in order to win the Western Division title over Seattle; as both teams had qualified for the postseason, Oakland was awarded the division title in the event of a tie on the basis of a 9-4 advantage in head-to-head play.
The Mariners and the defending World Series champion Yankees went on to meet in the AL Championship Series for the right to advance to the 2000 World Series against the National League champion New York Mets.
Umpires: Charlie Reliford, Kerwin Danley, Mike Reilly, Mike Winters, Rick Reed, Doug Eddings (Seattle-Chicago, Games 1-2; New York-Oakland, Games 3-5); Tim Welke, Chuck Meriwether, Tim McClelland, Paul Schrieber, Al Clark, Jeff Nelson (New York-Oakland, Games 1-2; Seattle-Chicago, Game 3)
Chicago White Sox vs. Seattle MarinersEdit
Seattle wins the series, 3-0
|1||Chicago||4||Seattle||7||October 3||1-0 (SEA)|
|2||Chicago||2||Seattle||5||October 4||2-0 (SEA)|
|3||Seattle||2||Chicago||1||October 6||3-0 (SEA)|
Oakland Athletics vs. New York YankeesEdit
New York wins the series, 3-2
|1||Oakland||5||New York||3||October 3||1-0 (OAK)|
|2||Oakland||0||New York||6||October 4||1-1|
|3||New York||4||Oakland||2||October 6||2-1 (NYY)|
|4||New York||1||Oakland||11||October 7||2-2|
|5||Oakland||5||New York||7||October 8||3-2 (NYY)|
|American League Division Series|