March 16 - A plane crash in Maracaibo, Venezuela kills 155 passengers including Carlos Santeliz, the Venezuelan League Rookie of the Year, on his way to the Braves' spring training camp. Another fatality is Néstor Chávez, en route to the Giants' camp. Chávez (1-0) was 12–5 with Double-A Waterbury in the Eastern League (1967), including seven shutouts. Pablo Torrealba was also scheduled to take the flight, but missed it and took a later one.
April 12 - At Detroit, the Yankees' Mel Stottlemyre allows just one hit, a 4th-inning double to Bill Northrup, and beats Denny McLain and the Detroit Tigers 4–0. For the 3rd time in two years, Northrup saves the Tigers from being the victims of a no-hitter.
May 1 - The Houston Astros, no-hit the day before by Jim Maloney of the Cincinnati Reds, answer back as Don Wilson pitches a 4-0 no-hitter, with 13 strikeouts over the Reds. Houston ties a National League record with just one assist. In Wilson's previous start against Cincinnati, on April 22, he gave up six runs in five innings in a 14-0 loss.
July 8 - With three runs in the 9th inning, the New York Mets beat the Chicago Cubs 4-3, cutting Chicago's lead in the National League East to four games. Chicago's Ron Santo rips into center fielder Don Young for two misplays in the outfield; Santo apologizes the next day for criticizing Young, who had left early and didn't take the team bus. Santo is later booed in his first game back at Wrigley Field.
August 14 - In the National League Eastern Division, the Chicago Cubs lead the St. Louis Cardinals by 8.5 games and the New York Mets by 9.5 games. The Mets win 38 out of their next 49 games, and the Cubs finish the season 8 games behind the Mets.
October 16 - In Game Five of the World Series at Shea Stadium, Donn Clendenon hit his third home run of the Series and pitcher Jerry Koosman completes the New York Mets' dominance over the Baltimore Orioles with a five-hit 5–3 victory. Clendenon is named World Series MVP. Al Weis gains the Babe Ruth Award from the N.Y baseball writers - an alternate form of the WS MVP Award.
January 23 - Al Bridwell, 85, shortstop whose apparent game-winning single for the New York Giants in a 1908 contest led to the controversial play in which baserunner Fred Merkle was eventually called out for not touching second base
February 19 - Doc White, 89, Chicago White Sox pitcher whose record of five consecutive shutouts was finally broken by Don Drysdale in 1968
March 14 - Heinie Zimmerman, 82, third baseman who was believed to have won the NL triple crown in 1912 (reversed by modern research; rbi title removed) but was barred from baseball in 1919 for his role in fixing games
March 16 - William Bell, 71, All-Star pitcher of the Negro Leagues who posted the highest career winning percentage in black baseball
March 21 - Pinky Higgins, 59, third baseman who held the AL record for career games at that position from 1944 to 1959, a 3-time All-Star and later manager of the Red Sox
May 5 - Eddie Cicotte, 84, pitcher who won 208 games for the Tigers, Red Sox and White Sox, but was thrown out of baseball as one of the eight "Black Sox" involved in fixing the 1919 World Series; he was the first of the eight to come forward, confessing his involvement and testifying before the grand jury
May 17 - Pants Rowland, 90, manager of the 1917 World Series champion Chicago White Sox, later president of the Pacific Coast League from 1944 to 1954
May 20 - Lee Allen, 54, historian at the Baseball Hall of Fame since 1959, former sportswriter
July 8 - Bill Carrigan, 85, manager and backup catcher for the Boston Red Sox' world champions in 1915 and 1916
September 29 - Tommy Leach, 91, third baseman and center fielder, primarily for the Pittsburgh Pirates, who led the NL in runs twice and home runs once
October 2 - Gordon Cobbledick, 70, sportswriter for the Cleveland Plain Dealer from 1928 to 1964
October 9 - Don Hoak, 41, third baseman who played on 1955 Brooklyn Dodgers and 1960 Pittsburgh Pirates World Series championship teams.
November 14 - Curt Roberts, 40, first black player in Pittsburgh Pirates history
November 15 - Billy Southworth, 76, Hall of Fame manager who won World Series titles in 1942 and 1944 with the St. Louis Cardinals and the 1948 NL pennant with the Boston Braves, posting a .597 career winning percentage. Southworth remains last NL manager to win 3 consecutive full-pennants (league championships). Southworth was finally selected to the Hall of Fame by the revamped Veterans' Committee in December, 2007.
December 7 - Lefty O'Doul, 72, left fielder who batted .349 in his career and won two batting titles after being converted from a pitcher; became the winningest manager in Pacific Coast League history, and earned additional fame as the "father" of professional baseball in Japan